In the laboratory we study the expression of genes involved in physiological processes and development in the model fly Drosophila melanogaster. These studies are aimed at understanding the responses of a living organism to different substances that can have potential beneficial or toxic effects. D. melanogaster allows us to identify genes that regulate specific metabolic pathways while providing data on vital parameters such as longevity, survival, mortality, and mutagenicity. Analyses, both molecular and of vital traits, are carried out in healthy flies but also in flies that model human diseases to have the broadest possible response. In particular, we study neurodegeneration, male fertility and aging. Among the substances with potential beneficial effects, we use bioactive molecules, DNA aptamers as well as extracts obtained from the agri-food industry waste, such as tomato pomace. At the same time D. melanogaster is used to evaluate the toxicity of environmental pollutants on human health and the environment.
Relevant instrumentation
- Real time PCR
- Microinjection Systems
- Stereoscopics
- Incubators
- Electroporator
| Chief Scientific Officer | Filomena Anna Digilio |
|---|---|
| Team | Ezia Costanzo |
| Contacts | E-mail: filomenaanna.digilio@cnr.it
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